Exploring the Safety and Satisfaction of Patients Injected With Collagen Biostimulators-A Prospective Investigation...

Area of Science:

• Aesthetic Medicine
• Dermatology
• Regenerative Medicine

Background:

• Non-surgical facial rejuvenation is increasingly popular, with poly-L-lactic acid (PLLA) gaining traction.
• Limited data exists on the safety and patient satisfaction of PLLA facial treatments.

Purpose of the Study:

• To evaluate the safety profile of PLLA treatment for facial rejuvenation.
• To assess patient satisfaction with PLLA treatment outcomes at mid- and long-term follow-up.

Main Methods:

• Prospective single-center study involving 52 female patients treated with Rennova Elleva (PLLA).
• Injections administered to the mid and lower face (zygomatic and pre-masseteric regions).
• Monthly clinical evaluations for 150 days, patient diaries for adverse effects, and Global Aesthetic Improvement Scale (GAIS) for satisfaction.

Main Results:

• Most reported adverse events (redness, pain, swelling) were mild, temporary, and resolved within days.
• One minor nodulation occurred, resolving spontaneously.
• GAIS scores remained stable from day 90 to day 150 (average 2.32), indicating sustained patient satisfaction.
• Duration of mild pain and bruising correlated inversely with GAIS scores.

Conclusions:

• Rennova Elleva (PLLA) demonstrates a favorable safety profile with minimal adverse effects.
• PLLA is effective for treating mild to moderate facial sagging, offering long-lasting, satisfactory aesthetic results.
• PLLA represents a valuable non-surgical option for facial rejuvenation.