Calcium Hydroxylapatite-Based Fillers in Facial Rejuvenation: A Prospective, Single-Center, Unblinded Comparative...

Area of Science:

• Dermatology
• Aesthetic Medicine
• Biomaterials Science

Background:

• Calcium hydroxylapatite (CaHA) fillers are popular for volumizing and biostimulation in esthetic medicine.
• Limited comparative data exists for different CaHA fillers' clinical outcomes.
• This study compares Rennova® Diamond Intense to Radiesse® for efficacy, safety, and satisfaction.

Purpose of the Study:

• To evaluate and compare the clinical performance of Rennova® Diamond Intense and Radiesse®.
• To assess safety and patient satisfaction with both CaHA fillers.
• To establish Rennova® Diamond Intense's efficacy in facial rejuvenation.

Main Methods:

• Prospective, single-center, unblinded study with 30 participants.
• Bilateral injection of Rennova® Diamond Intense and Radiesse® in the lower and medial posterior facial regions.
• Outcomes measured: dermal thickness, skin elasticity, transepidermal water loss, patient/physician-reported outcomes, and adverse events.

Main Results:

• Both fillers improved dermal thickness, skin elasticity, and reduced transepidermal water loss.
• Patient-reported outcomes showed 'improved' results; physician assessments indicated 'very improved' results by day 120.
• Mild, transient adverse events (pain, swelling, redness, bruising) resolved within 30 days.

Conclusions:

• Rennova® Diamond Intense is effective for increasing dermal thickness and improving skin quality.
• The filler demonstrates high patient and physician satisfaction, comparable to Radiesse®.
• Findings support Rennova® Diamond Intense's safety and efficacy for facial rejuvenation, with a need for further long-term studies.