Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

170
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
170
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

133
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
133

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Embedding Multiperspective Reflections in Co-Producing a Training Intervention for Care Home Staff: Understanding Group Members' Journeys and Impacts.

Health expectations : an international journal of public participation in health care and health policy·2026
Same author

Efficacy and Safety of the Selective, Brain-Penetrant P2X7 Receptor Antagonist JNJ-55308942 (Zanvipixant) in Bipolar Depression: A Phase 2a Study.

Biological psychiatry global open science·2026
Same author

A phase 1 evaluation of inhaled oxytocin: Physiologically-based pharmacokinetic model informed dosing of a novel heat-stable oxytocin delivery system.

British journal of clinical pharmacology·2026
Same author

Nail Bed Sporotrichosis in a Patient with Psoriasis Arthritis Treated with a TNF Blocker: A Case Report.

Skin appendage disorders·2026
Same author

Efficacy and safety of adjunctive treatment with the fatty acid amide hydrolase inhibitor JNJ-42165279 in participants with major depressive disorder with anxious distress: A double-blind, placebo-controlled, randomised study.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2026
Same author

Effective treatment of hydroplasty injections and immediate physical therapy for glenohumeral adhesive capsulitis: a retrospective clinical analysis.

JSES international·2025

Related Experiment Video

Updated: Jun 5, 2025

Spatial Quantification of Drugs in Pulmonary Tuberculosis Lesions by Laser Capture Microdissection Liquid Chromatography Mass Spectrometry LCM-LC/MS
09:58

Spatial Quantification of Drugs in Pulmonary Tuberculosis Lesions by Laser Capture Microdissection Liquid Chromatography Mass Spectrometry LCM-LC/MS

Published on: April 18, 2018

9.0K

Bedaquiline Monotherapy for Multibacillary Leprosy.

Jaison Barreto1, Patricia Sammarco Rosa1, Linda Adams1

  • 1From the Research Division, Instituto Lauro de Souza Lima, Bauru (J.B., P.S.R.), and Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta, Manaus (P.F.B.R.) - both in Brazil; the Department of Health and Human Services, Health Resources and Services Administration, Health Systems Bureau, National Hansen's Disease Program, Laboratory Research Branch, Baton Rouge, LA (L.A., R.T.); Translational Medicine and Early Development Statistics (S.Y.), WAVE Team (Z.A., S.R.C., S.K., D.M., J.A.P., M.W.), Janssen Research and Development, San Diego, CA; Janssen Global Public Health, Janssen Research and Development, Titusville, NJ (N.B., R.D.A.); and Janssen Global Public Health, Janssen Pharmaceutica, Beerse, Belgium (E.E., N.L., B.R.).

The New England Journal of Medicine
|December 12, 2024
PubMed
Summary

Bedaquiline monotherapy effectively cleared Mycobacterium leprae in leprosy patients within 4 weeks and improved skin lesions by 7 weeks, offering a potentially safer alternative to standard multidrug therapy.

More Related Videos

An In Vitro Caseum Binding Assay that Predicts Drug Penetration in Tuberculosis Lesions
12:17

An In Vitro Caseum Binding Assay that Predicts Drug Penetration in Tuberculosis Lesions

Published on: May 8, 2017

11.8K
Optimized Protocols for Mycobacterium leprae Strain Management: Frozen Stock Preservation and Maintenance in Athymic Nude Mice
10:32

Optimized Protocols for Mycobacterium leprae Strain Management: Frozen Stock Preservation and Maintenance in Athymic Nude Mice

Published on: March 23, 2014

15.0K

Related Experiment Videos

Last Updated: Jun 5, 2025

Spatial Quantification of Drugs in Pulmonary Tuberculosis Lesions by Laser Capture Microdissection Liquid Chromatography Mass Spectrometry LCM-LC/MS
09:58

Spatial Quantification of Drugs in Pulmonary Tuberculosis Lesions by Laser Capture Microdissection Liquid Chromatography Mass Spectrometry LCM-LC/MS

Published on: April 18, 2018

9.0K
An In Vitro Caseum Binding Assay that Predicts Drug Penetration in Tuberculosis Lesions
12:17

An In Vitro Caseum Binding Assay that Predicts Drug Penetration in Tuberculosis Lesions

Published on: May 8, 2017

11.8K
Optimized Protocols for Mycobacterium leprae Strain Management: Frozen Stock Preservation and Maintenance in Athymic Nude Mice
10:32

Optimized Protocols for Mycobacterium leprae Strain Management: Frozen Stock Preservation and Maintenance in Athymic Nude Mice

Published on: March 23, 2014

15.0K

Area of Science:

  • Infectious Diseases
  • Dermatology
  • Pharmacology

Background:

  • Standard multidrug therapy (MDT) for leprosy can cause severe side effects, exacerbating stigma.
  • Drug-resistant leprosy necessitates novel treatment strategies and safer regimens.
  • Alternative drug combinations are crucial for effective leprosy management.

Purpose of the Study:

  • To evaluate the efficacy and safety of bedaquiline monotherapy in previously untreated multibacillary leprosy patients.
  • To assess the impact of bedaquiline on Mycobacterium leprae viability and clinical symptoms.
  • To explore bedaquiline as a potential component of shorter, safer leprosy treatment regimens.

Main Methods:

  • Open-label, proof-of-concept study in Brazil.
  • Eight weeks of bedaquiline monotherapy followed by standard MDT.
  • Primary endpoint: change in Mycobacterium leprae growth in mouse footpads.
  • Secondary endpoint: safety and tolerability.

Main Results:

  • Complete clearance of Mycobacterium leprae by 4 weeks of bedaquiline monotherapy.
  • Significant improvement in skin lesions observed by 7 weeks.
  • All adverse events were mild (grade 1 or 2).

Conclusions:

  • Bedaquiline monotherapy demonstrates rapid bactericidal activity against Mycobacterium leprae.
  • Early clinical improvement in leprosy symptoms was observed with bedaquiline treatment.
  • Bedaquiline shows promise as a component of novel, safer leprosy treatment regimens.