FeCl₃ and GdCl₃ solutions as superfast relaxation modifiers for agarose gel: a quantitative analysis

This study aimed to evaluate the relaxivity and uniformity of agarose gel phantoms added with relaxation modifiers. It is hypothesized that the modifiers could manipulate the T1 and T2 relaxations as well as the signal uniformity.

Twenty agarose gel phantoms with different GdCl₃ and FeCl₃ volume fractions were prepared. The phantoms were scanned using a 3-T scanner implementing a turbo spin echo sequence to acquire T1 and T2 images. The SNR of the images were computed using Image-J software from 1, 3, and 25 regions-of-interest (ROIs) and were inverted as T1 and T2 curves.

With the increase in relaxation modifier content, T1 SNR increased at a faster rate at very short TR and reached saturation at TR well below 400 ms. Agarose gel phantoms containing GdCl₃ showed a higher saturation value as compared to phantoms containing FeCl₃. For T2 SNR, differences between plots are observed at low TE. As TE gets larger, the SNR between plots is incomparable. The SNR for both groups was uniform among 1, 3, and 25 ROIs.

It can be concluded that GdCl₃ and FeCl₃ solutions can be used as effective relaxation modifiers to reduce T1 but not T2 relaxation times.