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Prevalence and Distribution of Unexpected Actionable Germline Pathogenic Variants Identified on Broad-Based Multigene

Kara K Landry1, Michael J DeSarno2, Lindsay Kipnis3

  • 1Division of Hematology and Oncology, Department of Medicine, University of Vermont Medical Center, Burlington, VT.

JCO Precision Oncology
|December 12, 2024
PubMed
Summary

Multigene panel testing (MGPT) in cancer patients revealed pathogenic variants (PVs) in 1.7% of cases, even when not predicted by personal or family history. These unexpected findings in actionable cancer genes may impact patient management.

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