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Updated: May 10, 2026
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Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
Published on: April 3, 2016
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Theranostic-Guided UV-A Light Corneal Wavefront Photo-Reshaping for Presbyopia Correction: A Preclinical Study
Marco Lombardo1,2, Giuseppe Massimo Bernava3, Sebastiano Serrao1,2
1Studio Italiano di Oftalmologia, Rome, Italy.
Journal of Biophotonics
|December 12, 2024
Summary
This study shows UV-A light corneal photo-reshaping can alter corneal shape and reduce spherical aberration. This incision-free method offers potential for presbyopia correction without impacting distance vision.
Area of Science:
- Ophthalmology
- Biomedical Engineering
- Corneal Science
Background:
- Presbyopia correction is a significant challenge in ophthalmology.
- Current refractive surgery techniques have limitations.
- Novel, incision-free approaches are needed to improve visual outcomes.
Purpose of the Study:
- To investigate the efficacy of a theranostic-guided UV-A light corneal photo-reshaping technique.
- To assess the impact on corneal elevation and wavefront aberration (WA).
- To evaluate its potential for presbyopia correction.
Main Methods:
- Utilized a specialized platform combining UV-A light and corneal iontophoresis for patterned riboflavin delivery.
- Assessed riboflavin distribution and concentration-driven photopolymerization.
- Measured corneal topography and wavefront aberration (WA) in human donor eyes.
Main Results:
- Achieved significant corneal steepening and smooth wavefront shaping.
- Observed a delay in central WA and advancement in the surrounding zone.
- Demonstrated a 50% reduction in corneal spherical aberration (5.0 mm pupil).
- Corneal optical quality (MTF) remained stable.
Conclusions:
- The theranostic-guided UV-A light corneal photo-reshaping is an effective incision-free technique.
- It can successfully alter corneal shape and reduce aberrations.
- This method shows promise for extending focal range and correcting presbyopia.
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