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Auditory evoked responses in multiple sclerosis. Wave I abnormality.

N P Verma, G E Lynn

    Archives of Otolaryngology (Chicago, Ill. : 1960)
    |January 1, 1985
    PubMed
    Summary
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    Multiple sclerosis (MS) patients showed subclinical auditory nerve involvement. Far-field short latency auditory evoked potentials (AEPs) revealed abnormalities in over 20% of those tested, indicating early eighth cranial nerve dysfunction.

    Area of Science:

    • Neuroscience
    • Audiology
    • Neurology

    Background:

    • Multiple sclerosis (MS) is a demyelinating disease affecting the central nervous system.
    • Auditory pathway involvement can occur in MS, but subclinical manifestations are not fully understood.

    Purpose of the Study:

    • To investigate subclinical auditory nerve involvement in patients with definite multiple sclerosis.
    • To assess the utility of auditory evoked potentials (AEPs) in detecting early eighth cranial nerve dysfunction in MS.

    Main Methods:

    • Far-field short latency auditory evoked potentials (AEPs) were recorded.
    • AEPs were obtained from 40 patients with definite MS and 20 healthy controls.
    • Pure tone audiometry was performed to confirm normal hearing thresholds.

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    Main Results:

    • Nine out of 40 MS patients (22.5%) exhibited abnormal wave I of the AEPs.
    • These patients had normal hearing confirmed by pure tone audiometry.
    • This suggests a subclinical auditory nerve abnormality.

    Conclusions:

    • A significant proportion of MS patients demonstrate subclinical involvement of the auditory portion of the eighth cranial nerve.
    • AEPs are a valuable tool for detecting early, asymptomatic eighth cranial nerve dysfunction in MS.
    • These findings highlight the potential for widespread neurological impact in MS, even in clinically unaffected sensory pathways.