The AICD interactome: implications in neurodevelopment and neurodegeneration

Area of Science:

• Neuroscience
• Molecular Biology
• Biochemistry

Background:

• Alzheimer's disease (AD) research focuses on amyloid precursor protein (APP) processing and amyloid plaque formation.
• Downstream products of APP processing, such as the APP intracellular domain (AICD), are gaining research attention.
• AICD's interactions are crucial for various central nervous system (CNS) cellular functions.

Purpose of the Study:

• To review the neuronal functions of AICD.
• To summarize the pathological roles of AICD in neurodegeneration.
• To elucidate the AICD interaction network in the context of AD.

Main Methods:

• Literature review of studies on APP processing and AICD.
• Analysis of AICD's interactions with binding partners.
• Synthesis of findings on AICD's role in neuronal function and pathology.

Main Results:

• AICD interactions regulate critical cellular events: transcriptional activity, cytoskeletal dynamics, neuronal growth, and apoptosis.
• AICD is implicated in both normal neuronal processes and neurodegeneration.
• The AICD interaction network is dynamic and influences neuronal network function.

Conclusions:

• AICD is a key player in CNS cellular processes with implications for AD pathogenesis.
• Understanding the AICD interaction network is vital for deciphering its dual role in neuronal health and disease.
• Further research into AICD's functions may reveal novel therapeutic targets for Alzheimer's disease.