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Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
Published on: October 29, 2013
Impact of Guest Orientation in Host-Guest Supramolecular Hydrogels
Christopher J Addonizio1, Adam S Braegelman1,2, Connor R Schmidt1
1Department of Chemical & Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Abstract:
Host-guest interactions have been increasingly explored for use in the dynamic physical cross-linking of polymeric precursors to form hydrogel networks. However, the orientation of guest motifs is restricted upon macromolecule conjugation. The implications of such restriction on both the kinetics and thermodynamics of the resulting host-guest supramolecular cross-links are poorly understood. Herein, guest cross-linking motifs from controlled regioisomers are demonstrated to yield distinct material properties. Moreover, the underlying phenomena point to a further unexpected impact of modular guest topology on the molecular scale in both the affinity and dynamics of supramolecular complex formation.
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