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Chemically modified chitosan as a functional biomaterial for drug delivery system
Devika Sajeev1, Aparna Rajesh1, R Nethish Kumaar1
1Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Kochi, 682041, Kerala, India.
Carbohydrate Research
|December 13, 2024
Summary
Modified chitosan, a natural polymer, offers enhanced biocompatibility and properties for advanced drug delivery systems. Nanotechnology integration further boosts its therapeutic potential for various conditions.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Nanotechnology
Background:
- Chitosan is a natural, biodegradable polymer supporting green chemistry principles.
- Its inherent biocompatibility, accessibility, and reactive amino groups allow for extensive modification.
- Chemical modification enhances chitosan's properties like water solubility and biological activity.
Purpose of the Study:
- To review research on modified chitosan-based drug delivery systems.
- To detail the properties, functionality, and applications of these advanced biomaterials.
- To highlight the role of nanotechnology in enhancing chitosan drug delivery capabilities.
Main Methods:
- Chemical modification of chitosan to improve its characteristics.
- Fabrication of modified chitosan into diverse drug delivery systems (membranes, beads, fibers, etc.).
- Integration of nanotechnology with modified chitosan for enhanced therapeutic delivery.
Main Results:
- Modified chitosan serves as an effective functional biomaterial for targeted drug delivery.
- Diverse chitosan-based systems are suitable for various drug delivery methods.
- Nanotechnology integration significantly enhances the delivery of various therapeutic agents.
Conclusions:
- Modified chitosan is a versatile and promising biomaterial for advanced drug delivery.
- Nanotechnology-enhanced chitosan systems offer significant potential for diverse therapeutic applications.
- Further research into modified chitosan drug delivery systems is warranted for optimized therapeutic outcomes.
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