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Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants
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No clear relationship between circadian rhythm and cerebral perfusion parameters in pediatric and early adult

Ronda Lun1, Anirudh Sreekrishnan2, Sarah Lee1

  • 1Department of Neurology - Division of Vascular Neurology, Stanford Hospital, Palo Alto, CA, United States of America.

Journal of the Neurological Sciences
|December 13, 2024
PubMed

Insights

Circadian rhythm does not appear to affect cerebral perfusion in pediatric and young adult stroke patients. This study found no significant link between time of day and perfusion parameters in this age group.

Area of Science:

  • Neurology
  • Radiology
  • Pediatrics

Background:

  • Circadian rhythm's influence on cerebral perfusion is known in adults with acute large vessel occlusion.
  • This influence has not been previously studied in pediatric and young adult populations.

Purpose of the Study:

  • To investigate the relationship between time of day and cerebral perfusion parameters in pediatric and young adult patients with acute large vessel occlusion.

Main Methods:

  • Utilized the United States RAPID Insights database (2018-2023) for computed tomography perfusion (CTP) scans in patients aged 2-25 years.
  • Excluded intracerebral hemorrhage cases and analyzed anterior circulation large vessel occlusion (LVO) cases.
  • Stratified imaging times into Night, Day, and Evening epochs and analyzed age by pre-defined strata.

Main Results:

  • Included 2415 CTP scans, with 307 identified as LVO.
  • LVOs showed significantly higher penumbral and mismatch volumes compared to the overall cohort.
  • No significant association was found between time of day and mismatch volumes in the LVO subgroup.

Conclusions:

  • Unlike in adults, time of day did not show a clear association with cerebral perfusion parameters in pediatric and young adult patients.
  • Further research may be needed to fully understand circadian influences in younger populations.
Abstract

Keywords:
Computed tomography perfusionIschemic strokeNeuroimagingPediatricPerfusionStrokeYoung adults

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