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[Hormonal and functional parameters in hyperprolactinaemia (author's transl)].

R Pavelka, R Schmid, W H Schneider

    Wiener Klinische Wochenschrift
    |December 1, 1979
    PubMed
    Summary

    Elevated prolactin levels in women correlate with menstrual irregularities. Higher prolactin levels are linked to more severe cycle disorders and diminished hormonal responses, indicating potential fertility impacts.

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    Area of Science:

    • Endocrinology
    • Reproductive Medicine

    Context:

    • Hyperprolactinemia, characterized by elevated serum prolactin levels, is a known factor influencing reproductive health.
    • This study investigates the relationship between varying degrees of hyperprolactinemia and menstrual cycle disorders in women with normal pituitary imaging.

    Purpose:

    • To correlate serum prolactin levels with the type and severity of menstrual cycle disorders.
    • To assess the pituitary and ovarian hormonal responses to various stimulation tests in relation to prolactin levels.

    Summary:

    • 58 women were grouped by serum prolactin levels (16-40, 41-80, >80 ng/ml). Hormonal tests included gestagen and clomiphene challenges, Gn-RH tests for pituitary function, and ovarian response to gonadotropins (in the highest prolactin group).
    • Mild disorders (luteal insufficiency, anovulatory cycles, oligomenorrhea) were associated with low-to-moderate hyperprolactinemia.

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  • Severe disorders (secondary and primary amenorrhea) were linked to prolactin levels >80 ng/ml, often accompanied by negative Gn-RH test results (61%) and reduced ovarian response to gonadotropins.

    • Impact:

    • Findings demonstrate a dose-dependent relationship between hyperprolactinemia and menstrual dysfunction.
    • Highlights the potential for impaired pituitary and ovarian function in severe hyperprolactinemia, impacting fertility.
    • Suggests that increased prolactin levels may negatively affect responses to other hormonal stimulation tests.