Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Regulation of Angiogenesis and Blood Supply

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...

Overview of the Vascular System

Overview of the Vascular System

The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Context-dependent regulation of endothelial inflammation and atherosclerosis by endothelial microRNA-33.

Atherosclerosis·2026

Same author

Emerging role of ceramides and other sphingolipids in atherosclerosis.

Atherosclerosis·2026

Same author

Impaired glycosylation promotes rapid transition to hepatocellular carcinoma in model of diet-induced steatotic liver disease.

The Journal of clinical investigation·2026

Same author

Editorial: Metabolic crosstalk between cancer cells and immune cells in the tumor microenvironment: cellular and molecular insights, and their therapeutic implications.

Frontiers in oncology·2025

Same author

Roles of endothelial cells during infection.

Current opinion in immunology·2025

Same author

Latrophilin mediates flow activation of Notch to control vascular endothelial phenotype and atherosclerosis.

bioRxiv : the preprint server for biology·2025

Search research articles

Related Experiment Video

Updated: Jun 14, 2025

Evaluation of Bioenergetic Function in Cerebral Vascular Endothelial Cells

Evaluation of Bioenergetic Function in Cerebral Vascular Endothelial Cells

Published on: November 19, 2016

Intracellular endothelial cell metabolism in vascular function and dysfunction.

Kathryn M Citrin¹, Balkrishna Chaube², Carlos Fernández-Hernando³

¹Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA; Yale Center for Molecular and System Metabolism, Yale University School of Medicine, New Haven, CT, USA; Department of Cellular and Molecular Physiology, Yale University, New Haven, CT, USA.

Trends in Endocrinology and Metabolism: TEM

|December 13, 2024

Summary

This summary is machine-generated.

Endothelial cells (ECs) are vital for blood vessel health. Their metabolic pathways, including lipid handling and fatty acid oxidation, change during diseases and can be targeted for new therapies.

Keywords:

angiogenesis atherosclerosis endometabolism endothelial cell lipid metabolism

More Related Videos

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

Isolation and Identification of Vascular Endothelial Cells from Distinct Adipose Depots for Downstream Applications

Isolation and Identification of Vascular Endothelial Cells from Distinct Adipose Depots for Downstream Applications

Published on: June 10, 2022

Related Experiment Videos

Last Updated: Jun 14, 2025

Evaluation of Bioenergetic Function in Cerebral Vascular Endothelial Cells

Evaluation of Bioenergetic Function in Cerebral Vascular Endothelial Cells

Published on: November 19, 2016

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

Isolation and Identification of Vascular Endothelial Cells from Distinct Adipose Depots for Downstream Applications

Isolation and Identification of Vascular Endothelial Cells from Distinct Adipose Depots for Downstream Applications

Published on: June 10, 2022

Area of Science:

Vascular Biology
Cellular Metabolism
Biomedical Research

Background:

Endothelial cells (ECs) line blood vessels, regulating vascular tone, oxidative stress, and permeability.
EC dysfunction contributes to increased permeability, leukocyte adhesion, and thrombosis.
Metabolic alterations in ECs are observed in various conditions like wound healing, cancer, atherosclerosis, and diabetes.

Purpose of the Study:

To review recent research on intracellular metabolic pathways in ECs.
To highlight how EC metabolism is tailored to specific functional needs.
To emphasize the importance of understanding EC metabolic signatures in health and disease.

Main Methods:

Review of current scientific literature on endothelial cell metabolism.
Analysis of diverse intracellular metabolic pathways, including lipid handling, glycolysis, and fatty acid oxidation (FAO).
Discussion of the link between EC metabolic changes and disease progression.

Main Results:

ECs possess diverse intracellular metabolic pathways crucial for their function.
Metabolic pathways such as lipid handling, glycolysis, and FAO are adapted to EC functional requirements.
EC metabolic signatures are altered in various pathological conditions.

Conclusions:

Understanding EC metabolic signatures is essential for basic vascular biology.
Targeting EC metabolic functions offers potential therapeutic strategies for vascular diseases.
Exploiting EC metabolism can lead to novel treatments for conditions like atherosclerosis and diabetes.