Related Experiment Video
Updated: Jun 5, 2025
Author Spotlight: Three-Dimensional Cephalometric Landmark Annotation Demonstration on Human Cone Beam Computed Tomography Scans
Published on: September 8, 2023
Exploring the complexities of cleidocranial dysplasia: Dental anomalies and treatment interventions
Yuchao Shi1, Jiayin Ren1, Kaili Wang1
1Department of Oral Medical Imaging, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Introduction:
Cleidocranial dysplasia (CCD) is a genetic disorder characterized by distinctive oral manifestations, making dental anomalies a key diagnostic criterion and treatment focus.
Methods:
We retrospectively enrolled 32 patients diagnosed with CCD with detailed dental records (19 males and 13 females; mean age, 20.5 years). The detailed characteristics of impacted permanent teeth and supernumerary teeth were analyzed, and treatment considerations and outcomes for the abnormal dentition were summarized.
Results:
Among permanent teeth, 43.53% were impacted. A significant variation in the likelihood of tooth impaction was observed depending on the tooth position. On the basis of nonlinear regression analysis, this study identified a clear trend correlating the probability of impacted teeth with the sequence of permanent tooth eruption, with this probability exhibiting a distinct increase followed by a decrease (with R2 values in female and male patients of 0.65 and 0.84, respectively). In addition, 27 patients (84.4%) had supernumerary teeth, with 206 supernumerary teeth identified, predominantly of the supplemental premolar type (75.73%). There was a correlation between the morphology of supplemental teeth and their locations in the dentition. Among 10 patients with follow-up periods of >2 years, 117 impacted teeth were recorded, 61 teeth were involved in the treatment, 16 (26.23%) erupted after the extraction of retained deciduous or supernumerary teeth, and 33 teeth (54.10%) were successfully erupted through orthodontic traction. However, orthodontic treatment requires an extended period, and the periodontal conditions of treated teeth may require long-term maintenance.
Conclusions:
This study reveals a potential relationship between tooth impaction and the sequence of tooth eruption. It also distinguishes the distribution and morphologic characteristics of supernumerary teeth in patients with CCD from those in the general population. In addition, by analyzing clinical data, this study provides a summary of treatment considerations and outcomes for abnormal dentition in patients with CCD.
Related Concept Videos
01:15Teeth
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
01:21Tooth Anatomy
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
01:08Overview of the Skull
The cranial vault surrounds and protects the brain and houses the middle and inner ear structures. This cavity is bounded superiorly by the rounded top of the skull, which...