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Measuring the efficacy of Serenoa repens (USPlus) extract with mobile uroflowmetry
Joshua Winograd1, John Lama1, Alia Codelia-Anjum2
1Department of Urology, Weill Cornell Medicine, New York City, New York, USA.
The Canadian Journal of Urology
|December 15, 2024
Summary
This study shows that a standardized USP-verified Saw Palmetto extract significantly improves lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH). The extract effectively alleviates symptoms and enhances quality of life.
Area of Science:
- Urology
- Pharmacognosy
- Men's Health
Background:
- Benign prostatic hyperplasia (BPH) is a common condition causing lower urinary tract symptoms (LUTS) in men.
- Phytotherapy, including Saw Palmetto extracts, is a popular alternative treatment for BPH.
- The efficacy of Saw Palmetto extract (Serenoa repens) for LUTS remains debated due to inconsistent research findings.
Purpose of the Study:
- To evaluate the effectiveness of a standardized, USP-verified Saw Palmetto extract in managing male LUTS associated with BPH.
- To address the controversy surrounding the efficacy of Saw Palmetto extract in clinical practice.
Main Methods:
- A prospective, single-arm clinical trial was conducted.
- Participants used a standardized USP-verified Saw Palmetto extract (320 mg daily).
- The ProudP mobile application facilitated home uroflowmetry and symptom assessment (IPSS, QoL).
Main Results:
- Significant improvements in International Prostate Symptom Score (IPSS) and Quality of Life (QoL) were observed at 12 weeks.
- Patients with moderate BPH symptoms showed particular benefit in symptom scores.
- Uroflowmetry indicated improved flow rates, especially in men with mild LUTS.
Conclusions:
- The study supports the use of a standardized USP-verified Saw Palmetto extract for alleviating LUTS in men with BPH.
- Further research with larger, diverse populations and extended follow-up is recommended to confirm these findings.
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