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Intelligent Generic High-Throughput Oscillatory Shear Technology Fabricates Programmable Microrobots for Real-Time
Xuqi Peng1, Haitian Tang1, Zhenwen Zhao1
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, State Key Laboratory of Vaccines for Infectious Diseases, Center for Molecular Imaging and Translational Medicine, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, 361102, China.
An intelligent manufacturing technology (iGHOST) creates programmable microrobots for precise endovascular embolization. These microrobots offer real-time visual guidance and drug delivery, overcoming current limitations in vascular treatments.
Area of Science:
- Biomedical Engineering
- Materials Science
- Robotics
Background:
- Precise delivery of microrobots for endovascular embolization is challenging in dynamic blood vessels.
- Current methods lack real-time visual guidance and efficient production capabilities.
Purpose of the Study:
- To develop an intelligent, high-throughput technology (iGHOST) for fabricating programmable, multifunctional microrobots.
- To enable real-time visual guidance for in vivo endovascular embolization.
- To address limitations in microrobot production and precision delivery.
Main Methods:
- Utilized machine learning (ML) to optimize synthesis parameters for microrobot fabrication.
- Developed an oscillatory shear technology (iGHOST) for continuous, purification-free microrobot production.
- Fabricated magnetically responsive lipiodol-calcium alginate (MagLiCA) microrobots.
Main Results:
- Achieved continuous production of uniform microrobots (400-1000 µm) at >240 mL/h.
- Demonstrated precise navigation and accurate embolization in liver and kidney models under X-ray imaging.
- Confirmed drug-loading capabilities for simultaneous embolization and targeted treatment.
Conclusions:
- The ML-optimized iGHOST process is an intelligent, rapid, and green method for producing size-controllable microrobots.
- MagLiCA microrobots enable precise, image-guided endovascular embolization with potential for drug delivery.
- This technology offers significant potential for various medical applications requiring precise in vivo treatment.
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