Endothelial mitochondrial content of cerebral cortical capillaries in Alzheimer's disease. An ultrastructural...

The mitochondrial content of endothelial cells of cerebral cortical capillaries in patients with Alzheimer's disease and age-matched controls was calculated using stereologic methods. No morphologic abnormalities or quantitative changes in endothelial mitochondria are reported. Our findings do not support the hypothesis of a blood-brain barrier defect in Alzheimer's disease.