Related Experiment Video
Updated: Jun 5, 2025

15:07
VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
Published on: December 28, 2015
26.6K
Diffuse Large B-Cell Lymphoma: Dramatic Evolution From Unilateral to Bilateral Leg Edema
Uta Shimada1, Yuichiro Mine2, Yuichi Takahashi2
1Clinical Training Center, Juntendo University Hospital, Tokyo, JPN.
Cureus
|December 16, 2024
Summary
Unilateral leg edema can signal diffuse large B-cell lymphoma (DLBCL). This case shows DLBCL can progress from unilateral to bilateral edema due to vascular compression.
Area of Science:
- Oncology
- Vascular Medicine
- Diagnostic Imaging
Background:
- Edema is typically classified as systemic (bilateral) or localized (unilateral).
- Lymphoma-associated leg edema is predominantly bilateral.
- Unilateral edema has been reported due to vascular compression, but is less common in lymphoma.

