Red Blood Cell-Related Parameters in Rheumatoid Arthritis: Clinical Value and Immunological Significance

Rheumatoid arthritis (RA) is characterized by chronic inflammation and autoimmunity. Moreover, the disease activity, co-morbidities, and prognosis of RA are closely associated with changes in red blood cell (RBC)-related parameters. The role of these parameters in RA has therefore been extensively studied. Accordingly, this article summarizes and analyzes the close relationship of RBC-related parameters such as RBC count, hemoglobin, and RBC distribution width with disease activity, co-morbidities, and prognosis in RA by reviewing the available literature. In addition, given the immunomodulatory functions of RBCs, their surface proteins, contents, and microparticles are involved in the immunomodulatory process during RA. Overall, this review aims to assess the important clinical value and immunological significance of RBCs and their related parameters in the monitoring and management of RA, thus providing a reference for the clinical diagnosis and treatment of RA and the direction for the research on RBC-related immunity.