Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

411
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
411
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

315
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
315
Drug Delivery: Overview01:16

Drug Delivery: Overview

276
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
276
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

377
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
377
Drug Distribution: Tissue Binding01:21

Drug Distribution: Tissue Binding

2.5K
Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
For...
2.5K
Biopharmaceutics and Pharmacokinetics: Overview01:28

Biopharmaceutics and Pharmacokinetics: Overview

1.8K
Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Untargeted metabolomics and proteomics reveals cocoa-mediated mitigation of valproic acid-induced dysregulation in a zebrafish model of autism: pilot study.

Metabolomics : Official journal of the Metabolomic Society·2026
Same author

Chd7 regulates lipid metabolism and swim bladder inflation in zebrafish.

Journal of lipid research·2026
Same author

PAICS mediates DNA damage and cerebellar neuronal loss in C9orf72 amyotrophic lateral sclerosis.

Brain : a journal of neurology·2026
Same author

Bottlebrush Polymer Templates for the Synthesis of Gold Nanostructures and their Applications as Photothermal Agents and SERS Substrates.

Small methods·2025
Same author

Rapid Quantification of Virus-Like Particles via Gold Nanoparticle Sensors and Dark-Field Differential Dynamic Microscopy.

ACS sensors·2025
Same author

Ion Valency as a Molecular Switch for Salt-Resistant Underwater Adhesion.

Advanced materials (Deerfield Beach, Fla.)·2025

Related Experiment Video

Updated: Jun 5, 2025

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform
06:27

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

Published on: October 20, 2020

5.1K

Core-Shell Bottlebrush Polymers: Unmatched Delivery of Small Active Compounds Deep Into Tissues.

Quoc Thang Phan1, Jean-Michel Rabanel1,2, Dikran Mekhjian1

  • 1Faculty of Pharmacy, Université de Montréal, 2940 Chemin de Polytechnique, Montréal, Québec, H3T 1J4, Canada.

Small (Weinheim an Der Bergstrasse, Germany)
|December 16, 2024
PubMed
Summary
This summary is machine-generated.

Bottlebrush (BB) polymers, with their unique structures, show improved drug delivery compared to traditional micelles. These advanced nanocarriers enhance cellular uptake and drug penetration for biomedical applications.

Keywords:
bottlebrush polymerdrug delivery systemmethacryloyloxyethyl phosphorylcholinepoly (D,L‐lactic acid)self‐assembly

More Related Videos

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

15.7K
Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles
09:27

Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles

Published on: August 16, 2012

10.7K

Related Experiment Videos

Last Updated: Jun 5, 2025

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform
06:27

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

Published on: October 20, 2020

5.1K
Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

15.7K
Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles
09:27

Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles

Published on: August 16, 2012

10.7K

Area of Science:

  • Polymer Chemistry
  • Nanotechnology
  • Biomedical Engineering

Background:

  • The efficacy of drug delivery systems is critically dependent on the nanovehicle's chemical structure.
  • Bottlebrush (BB) polymers offer tunable architectures (backbone length, grafting density, morphology) for novel drug delivery applications.

Purpose of the Study:

  • To develop and evaluate core-shell BB polymers as drug delivery nanocarriers.
  • To investigate the impact of BB polymer structure on drug loading, cellular uptake, and penetration.
  • To compare BB-based nanocarriers with conventional polymeric micelles (PM).

Main Methods:

  • Synthesis of core-shell BB polymers via a "grafting-from" strategy.
  • Characterization using Nuclear Magnetic Resonance (NMR), Gel Permeation Chromatography (GPC), and Atomic Force Microscopy (AFM).
  • Evaluation of drug loading efficiency and cellular penetration using Rhodamine B and Paclitaxel.

Main Results:

  • BB polymers were successfully synthesized and characterized.
  • BB-based nanocarriers demonstrated superior cellular uptake in 2D and 3D models compared to PM.
  • Polymer morphology significantly influenced biological interactions, drug distribution, and particle penetration.

Conclusions:

  • Precisely structured unimolecular BB carriers show significant potential for enhanced drug delivery.
  • BB polymers represent a promising platform for diverse biomedical applications requiring efficient drug transport.