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Neonatal thrombosis.

D R Barnard, W E Hathaway

    The American Journal of Pediatric Hematology/Oncology
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Newborns may have a tendency towards thrombosis due to various factors. However, physiological platelet dysfunction and increased fibrinolysis likely protect most infants.

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    Area of Science:

    • Neonatal physiology
    • Hematology
    • Thrombosis research

    Background:

    • Neonatal thrombotic tendency is a complex issue.
    • Potential contributing factors include blood flow, vessel walls, procoagulants, anticoagulants, and the reticuloendothelial system.

    Purpose of the Study:

    • To explore the multifactorial causes of thrombosis in newborns.
    • To understand the relative importance of each contributing factor.

    Main Methods:

    • Review of existing literature on neonatal hemostasis.
    • Analysis of potential etiological factors for thrombosis in infants.

    Main Results:

    • The precise role of individual factors in neonatal thrombosis remains largely undetermined.
  • Physiological platelet dysfunction in infants may offer protection.

    • Conclusions:

    • Neonatal thrombosis is influenced by a combination of factors.
    • Increased fibrinolysis and coagulation factor deficiencies are key protective mechanisms in most infants.