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Neonatal thrombosis
The American Journal of Pediatric Hematology/Oncology
|January 1, 1979
Insights
Newborns may have a tendency towards thrombosis due to various factors. However, physiological platelet dysfunction and increased fibrinolysis likely protect most infants.
Area of Science:
- Neonatal physiology
- Hematology
- Thrombosis research
Background:
- Neonatal thrombotic tendency is a complex issue.
- Potential contributing factors include blood flow, vessel walls, procoagulants, anticoagulants, and the reticuloendothelial system.
Purpose of the Study:
- To explore the multifactorial causes of thrombosis in newborns.
- To understand the relative importance of each contributing factor.
Main Methods:
- Review of existing literature on neonatal hemostasis.
- Analysis of potential etiological factors for thrombosis in infants.
Main Results:
- The precise role of individual factors in neonatal thrombosis remains largely undetermined.
- Physiological platelet dysfunction in infants may offer protection.
Conclusions:
- Neonatal thrombosis is influenced by a combination of factors.
- Increased fibrinolysis and coagulation factor deficiencies are key protective mechanisms in most infants.
Abstract:
Abnormalities in blood flow, in blood vessel walls, in procoagulants, in circulating anticoagulants, and in the reticuloendothelial system may contribute to the thrombotic tendency of newborns. However, the importance of the role of each of these factors or other unmeasured factors is largely unknown. Most infants may be protected by their physiologic platelet dysfunction, increased fibrinolysis, and deficiencies in coagulation factors.