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Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

Updated: Jun 5, 2025

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Primary angle-closed diseases recognition through artificial intelligence-based anterior segment-optical coherence

Haipei Yao1, Xiaolei Wang2, Yan Suo1

  • 1Department of Ophthalmology, Shanghai Eye Diseases Prevention &Treatment Center/ Shanghai Eye Hospital, School of Medicine, Tongji University, Shanghai, China.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|December 16, 2024
PubMed
Summary

Artificial intelligence (AI) deep learning effectively classifies anterior chamber angles from anterior segment-Optical Coherence Tomography (AS-OCT) images. This automated analysis improves efficiency for detecting angle closure glaucoma risk.

Keywords:
Anterior chamber angle assessmentAnterior segment optical coherence tomography (AS-OCT)Deep learningPrimary angle-closed disease

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Artificial Intelligence

Background:

  • Anterior segment-Optical Coherence Tomography (AS-OCT) is crucial for evaluating anterior chamber angle.
  • Automated analysis of AS-OCT images can enhance diagnostic efficiency.
  • Glaucoma screening and prevention efforts benefit from improved imaging analysis.

Purpose of the Study:

  • To develop and evaluate an AI system for automated classification of anterior chamber angles using AS-OCT images.
  • To improve the efficiency and accuracy of AS-OCT image analysis in clinical settings.
  • To identify individuals at high risk for primary angle closure glaucoma (PACG) through automated image analysis.

Main Methods:

  • A deep learning model was developed using AS-OCT images from a glaucoma screening project.
  • The dataset comprised 94,895 AS-OCT images from 687 participants.
  • Classifier performance was assessed against expert grading, using accuracy and area under the receiver operator curve (AUC).

Main Results:

  • The best-performing classifier, based on ResNet-50 architecture with transfer learning, achieved an AUC of 0.9635.
  • The system demonstrated high accuracy in distinguishing between open and closed anterior chamber angles.
  • A class-balanced dataset of 22,393 images was used for training the classifier.

Conclusions:

  • Deep learning classifiers can effectively detect angle closure from AS-OCT images.
  • The developed AI system automates clinical evaluations of the anterior chamber angle, enhancing efficiency.
  • This technology shows potential for rapid identification of populations at high risk for PACG.