Phenalenones and Polyesters from Talaromyces stipitatus and Structure Revision of Talaromycesone A
Nirmal K Chaudhary1, Daniel Vuong2, Ernest Lacey1,2
1School of Natural Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.
Abstract:
Investigation of the secondary metabolites of the filamentous fungus Talaromyces stipitatus led to the isolation of two new phenalenone dimers, talarohemiketal A (1) and talaroazasone A (2), and one new macrolide polyester, talaromacrolactone A (3), along with the reported oxyphenalenone dimers talaromycesone A (4), bacillisporin A (5), bacillisporin B (6), bacillisporin C (7), epi-bacillisporin F (8), and bacillisporin J (9), the phenalenone monomer funalenone (10), the polyesters 15G256α (11) and 15G256ν (12), and 6-hydroxymellein (13). Detailed analysis of 2D NMR correlations, supported by TDDFT calculations, led to the structural revision of talaromycesone A as 4 from previously reported structure 14. In addition, the previously misassigned NMR spectra of compound 8 have been corrected.
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