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Updated: Jun 5, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Two new sesquiterpene eudesmanolides from the Croton cascarilloides Raeusch
Tian-Yi Liu1, Hong-Li Liu1, Xi Jiang1
1State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, People's Republic of China.
Abstract:
Two new sesquiterpene eudesmanolides, 5α-hydroxy-eudesman-7(11)-en-8α(12)-olide (1), and 5α-hydroxy-7(11)-en-8-oxo-eudesmane (2), along with six known sesquiterpene eudesmanolides, were isolated from the leaves and twigs of Croton cascarilloides Raeusch. The structures of these compounds were established basis on NMR and MS spectroscopic analyses. The cytotoxic activities of the isolated compounds were evaluated. Compounds 6 (IC50 115.38 ± 8.81 μg/mL) and 8 (IC50 72.04 ± 1.92 μg/mL) showed inhibitory activity against HL-60 leukaemia cells, while compounds 2 exhibited inhibitory activity against both HL-60 leukaemia cells (IC50 178.34 ± 6.43 μg/mL) and SMMC-7721 hepatoma cells (IC50 188.87 ± 7.40 μg/mL).
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