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A Systematic Review on the Antimicrobial Activity of Andrographolide.
Gayus Sale Dafur1,2, Aiza Harun3, Tuan Noorkorina Tuan Kub1
1Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan 16150, Malaysia.
Journal of Microbiology and Biotechnology
|December 16, 2024
Summary
Andrographolide shows antimicrobial potential against bacteria, viruses, and protozoa, but has limited antifungal effects. Further research is needed to explore its use in combating antimicrobial resistance.
Area of Science:
- Phytochemistry
- Microbiology
- Pharmacology
Background:
- Andrographolide, a compound from *Andrographis paniculata*, possesses antimicrobial properties.
- It is used in traditional medicine and shows promise against antimicrobial resistance.
- A systematic review was conducted to evaluate its efficacy.
Purpose of the Study:
- To synthesize data on andrographolide's antimicrobial activity.
- To assess its potential in combating antimicrobial resistance.
- To identify research gaps in its application.
Main Methods:
- A systematic review of 16 peer-reviewed studies (2010-2024) following PRISMA 2020 guidelines.
- Quality and bias risk assessment using the In Vitro Quality Evaluation Instrument.
- Analysis of andrographolide's effects on bacteria, viruses, fungi, and protozoa.
Main Results:
- Effective against bacteria (*E. coli*, *K. pneumoniae*, *S. aureus*), viruses (2019-nCoV, Dengue, Enterovirus D68), and protozoa (*P. falciparum*, *S. cervi*).
- Limited antifungal activity; ineffective against *C. albicans* and *S. cerevisiae*, but effective against *A. solani*.
- 11 studies (78.57%-92.86%) had low bias risk, 5 had medium bias risk (57.14%-64.29%).
Conclusions:
- Andrographolide demonstrates broad-spectrum antimicrobial potential, particularly against bacteria and viruses.
- Its antifungal efficacy is specific and requires further investigation.
- Further research is essential for understanding mechanisms, safety, and applications in antimicrobial resistance strategies.
