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Updated: Jun 5, 2025
Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Silver-Catalyzed Markovnikov Addition Hydrofunctionalization of Terminal Alkynes: Synthesis of N-Enoxyimides and
Hafiz Noor1,2, Shuwei Zhang1, Xiaodong Jia1
1College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
Abstract:
N-Enoxyimides are versatile and valuable synthetic synthons in modern organic synthesis and catalysis. Herein, a silver-catalyzed hydrooxyimidation of terminal alkynes that enables the synthesis of N-enoxyimides, has been demonstrated. The protocol features are simple, step- and atom-efficient, scalable, and exhibit a broad scope of functional group tolerance under mild conditions. A novel hydrolysis of the N-enoxyimides unexpectedly provides the corresponding aromatic oximes in 96% yield, showing the potential application of this strategy.
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