Prognostic Impact of Multiple Synchronous T1 Breast Cancer

Area of Science:

• Oncology
• Breast Cancer Research
• Surgical Oncology

Background:

• The incidence of multiple breast cancers is highly variable, influenced by detection methods and definitions.
• Improved imaging techniques have enhanced the detection of multiple breast cancers.
• The prognostic impact of multiple breast cancers remains debated.

Purpose of the Study:

• To investigate the association between the number of synchronous ipsilateral T1 breast tumors and survival.
• To compare overall survival (OS) and breast cancer-specific survival (BCSS) based on tumor multiplicity.

Main Methods:

• Retrospective analysis of 45,881 invasive breast cancer patients undergoing surgery (2004-2016).
• Patients grouped by tumor count: one, two, or three or more synchronous ipsilateral T1 tumors.
• Comparison of OS and BCSS across these groups.

Main Results:

• No significant survival difference between one and two synchronous ipsilateral T1 tumors.
• Patients with three or more tumors showed significantly lower OS and BCSS.
• Multivariate analysis identified three or more tumors as an independent risk factor for poorer survival.

Conclusions:

• Synchronous ipsilateral T1 breast cancer with three or more tumors is associated with a worse prognosis.
• These patients may benefit from escalated treatment approaches.
• Further research into tailored treatment strategies for multiple T1 tumors is warranted.