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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Related Experiment Video

Updated: Jun 5, 2025

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
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Current Treatment Methods in Hepatocellular Carcinoma.

Kamila Krupa1, Marta Fudalej2,3, Anna Cencelewicz-Lesikow3

  • 1Students' Scientific Organization of Cancer Cell Biology, Department of Oncological Propaedeutics, Medical University of Warsaw, 01-445 Warsaw, Poland.

Cancers
|December 17, 2024
PubMed
Summary

Hepatocellular carcinoma (HCC) treatments range from surgery and transplantation for early stages to targeted therapies and immunotherapies for advanced disease. Novel combinations are being explored to improve patient outcomes.

Keywords:
TACETAREatezolizumabhepatocellular carcinomaimmunotherapylenvatinibnivolumabpembrolizumabradiation therapysorafenib

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Area of Science:

  • Hepatology
  • Oncology
  • Translational Medicine

Background:

  • Hepatocellular carcinoma (HCC) is a significant global health concern.
  • Conventional chemotherapy and radiotherapy show limited efficacy in HCC treatment.
  • Treatment strategies must be tailored to tumor stage and liver function.

Purpose of the Study:

  • To review the current landscape of HCC treatment modalities.
  • To highlight recent clinical findings and emerging therapeutic approaches.
  • To discuss the evolving role of targeted therapies and immunotherapies.

Main Methods:

  • Literature review of current HCC treatment options.
  • Analysis of FDA-approved therapies for advanced HCC.
  • Examination of ongoing clinical trials and novel treatment combinations.

Main Results:

  • Radiofrequency ablation (RFA), surgical resection, and transarterial chemoembolization (TACE) are approved for advanced HCC.
  • Liver transplantation is a primary option for early-stage HCC.
  • Tyrosine kinase inhibitors (TKIs), immunotherapy, and anti-angiogenesis agents represent advanced treatment options.

Conclusions:

  • Treatment for HCC is stage-dependent, with diverse options available.
  • Combination therapies involving immune checkpoint inhibitors (ICIs) show promise.
  • Ongoing research focuses on optimizing treatment strategies for improved HCC patient outcomes.