Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bacterial Signaling01:30

Bacterial Signaling

Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
Microbial Corrosion01:24

Microbial Corrosion

Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Broad-Spectrum Antimicrobial Activity of a Ruthenium(II) Polypyridyl Complex against Multidrug-Resistant Uropathogens and Biofilms.

ACS omega·2026
Same author

Neat deep eutectic solvents exhibit potent antibiofilm activity: overcoming dilution bias in eutectic solvent antimicrobial assays.

Journal of applied microbiology·2026
Same author

Uncovering the Secret of Mesenchymal Stromal Cells Secretome: From Extracellular Vesicle Cargo to Neuroprotection.

Cells·2026
Same author

Amino Acid-Coated Nanoparticles for Preservation of Cut Roses: Formulation and Performance.

ACS omega·2026
Same author

Antifungal activity of metal-based coatings on polytunnel surfaces.

Journal of applied microbiology·2026
Same author

Investigating the Role of Diet-Manipulated Gut Bacteria in Pathogenesis of Type 2 Diabetes Mellitus-An <i>In Vitro</i> Approach.

Nutrients·2026
Same journal

RETRACTED: Al-Hussain et al. Application of New Sodium Vinyl Sulfonate-co-2-Acrylamido-2-me[thylpropane Sulfonic Acid Sodium Salt-Magnetite Cryogel Nanocomposites for Fast Methylene Blue Removal from Industrial Waste Water. <i>Nanomaterials</i> 2018, <i>8</i>, 878.

Nanomaterials (Basel, Switzerland)·2026
Same journal

Correction: Jiang et al. Methods for Obtaining One Single Larmor Frequency, Either <i>v</i><sub>1</sub> or <i>v</i><sub>2</sub>, in the Coherent Spin Dynamics of Colloidal Quantum Dots. <i>Nanomaterials</i> 2023, <i>13</i>, 2006.

Nanomaterials (Basel, Switzerland)·2026
Same journal

Correction: Ekman et al. Synthesis, Characterization, and Adsorption Properties of Nitrogen-Doped Nanoporous Biochar: Efficient Removal of Reactive Orange 16 Dye and Colorful Effluents. <i>Nanomaterials</i> 2023, <i>13</i>, 2045.

Nanomaterials (Basel, Switzerland)·2026
Same journal

Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub>-Based Materials and Coatings for De-Icing and Defogging of Wind Turbine Blades: Materials Basis, Structural Design, Engineering Integration, and Future Opportunities.

Nanomaterials (Basel, Switzerland)·2026
Same journal

Influence of the Ripeness Stages of the Precursors on the Optical Characteristics of Carbon Dots Obtained from Valencia Orange Peels (<i>Citrus sinensis</i> L. Osbeck) by Hydrothermal Synthesis.

Nanomaterials (Basel, Switzerland)·2026
Same journal

Insights into ALD Growth of Al-Based Dielectric Stack on 4H-SiC.

Nanomaterials (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: Jun 25, 2026

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance
06:42

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance

Published on: September 27, 2024

1.5K

Surface-Functionalised Copper Oxide Nanoparticles: A Pathway to Multidrug-Resistant Pathogen Control in Medical

James Hall1, Subbareddy Mekapothula1, Rebecca Coxhill1

  • 1School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK.

Nanomaterials (Basel, Switzerland)
|December 17, 2024
PubMed
Summary
This summary is machine-generated.

Glutamic acid-coated copper oxide nanoparticles (GA-CuONPs) provide potent antimicrobial coatings for medical devices. This innovation combats antibiotic resistance by effectively targeting bacteria without harming human cells.

Keywords:
3-mercaptopropyltrimethoxysilaneCDC reactorESKAPE pathogensGlu–CuO nanoparticlesMPTMSantimicrobial activitycopper oxide nanoparticlesglutamic acidmulti-drug resistancetissue culture

More Related Videos

Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria
05:57

Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria

Published on: October 4, 2024

766
Studying Copper Nanoparticle-Induced Programmed Cell Death in Bacteria
08:11

Studying Copper Nanoparticle-Induced Programmed Cell Death in Bacteria

Published on: May 16, 2025

58

Related Experiment Videos

Last Updated: Jun 25, 2026

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance
06:42

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance

Published on: September 27, 2024

1.5K
Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria
05:57

Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria

Published on: October 4, 2024

766
Studying Copper Nanoparticle-Induced Programmed Cell Death in Bacteria
08:11

Studying Copper Nanoparticle-Induced Programmed Cell Death in Bacteria

Published on: May 16, 2025

58

Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Antibiotic resistance is a growing global health threat.
  • Copper oxide nanoparticles (CuONPs) show potential as antimicrobial agents.
  • Medical devices require effective antimicrobial surfaces to prevent infections.

Purpose of the Study:

  • To synthesize and characterize glutamic acid-coated copper oxide nanoparticles (GA-CuONPs).
  • To functionalize medical-grade silicone tubing with GA-CuONPs.
  • To evaluate the antimicrobial efficacy and biocompatibility of the coated silicone.

Main Methods:

  • Synthesis of GA-CuONPs using glutamic acid.
  • Functionalization of silicone tubing with GA-CuONPs via an oxysilane bonding agent.
  • Antimicrobial testing against Gram-positive and Gram-negative bacteria, including multidrug-resistant strains.
  • Cytotoxicity assays using human cells.
  • Adherence and leaching tests.

Main Results:

  • GA-CuONPs exhibited significant antimicrobial activity against a broad spectrum of bacteria.
  • The GA-CuONP coating demonstrated no toxicity to human cells.
  • The coating showed stable adherence to silicone tubing without leaching.
  • Effective functionalization was achieved using the oxysilane bonding agent.

Conclusions:

  • GA-CuONP coatings offer a promising strategy for enhancing the antimicrobial properties of medical devices.
  • This method provides a versatile approach for both manufacturing and ad hoc modification of medical equipment.
  • The developed coating addresses the critical need for solutions against antibiotic-resistant pathogens.