Controlling Nutritional Status (CONUT) Score as Prognostic Indicator in Stage IV Gastric Cancer with Chronic...

Area of Science:

• Oncology
• Gastroenterology
• Nutritional Science

Background:

• Advanced gastric cancer frequently leads to chronic intestinal failure (CIF).
• Home parenteral nutrition (HPN) is a critical intervention for managing CIF.
• Predicting survival in these complex patients remains challenging.

Purpose of the Study:

• To investigate the correlation between the Controlling Nutritional Status (CONUT) index and survival outcomes.
• To assess the utility of the CONUT index in patients with TNM stage IV gastric cancer requiring HPN.

Main Methods:

• A cohort of 410 patients with CIF due to advanced gastric cancer (2015-2023) was analyzed.
• Controlling Nutritional Status (CONUT) scores, BMI, and biochemical data were collected.
• Cox proportional hazards models and logistic regression were employed to evaluate survival predictors and malnutrition classification.

Main Results:

• CONUT scores were identified as independent predictors of survival.
• Higher CONUT scores significantly correlated with increased mortality risk (HR = 2.073, p < 0.001).
• The predictive model demonstrated 71% overall accuracy in classifying patient outcomes.

Conclusions:

• The CONUT index is a valuable tool for predicting survival in patients with HPN-dependent CIF secondary to stage IV gastric cancer.
• Nutritional status assessment using CONUT scores can aid in risk stratification and clinical management decisions.