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Related Experiment Video

Updated: Jun 4, 2025

Protocol for Microplastics Sampling on the Sea Surface and Sample Analysis

Protocol for Microplastics Sampling on the Sea Surface and Sample Analysis

Published on: December 16, 2016

Invisible but Insidious Effects of Microplastics.

Natalia A Stefanova^1,2, Yulia S Sotnikova³, Aleksandra E Osechkova³

¹Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Lavrentjev Avenue 10, 630090 Novosibirsk, Russia.

Molecules (Basel, Switzerland)

|December 17, 2024

Summary

Microplastics (MPs) exposure negatively impacts cognitive function in rats, potentially accelerating aging and affecting lifespan. Higher doses exacerbated age-related eye conditions like cataracts and AMD.

Keywords:

Alzheimer’s disease OXYS rats age-related macular degeneration cognitive ability memory microplastic polymers

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Last Updated: Jun 4, 2025

Protocol for Microplastics Sampling on the Sea Surface and Sample Analysis

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Sampling, Sorting, and Characterizing Microplastics in Aquatic Environments with High Suspended Sediment Loads and Large Floating Debris

Sampling, Sorting, and Characterizing Microplastics in Aquatic Environments with High Suspended Sediment Loads and Large Floating Debris

Published on: July 28, 2018

Area of Science:

Environmental Health
Toxicology
Aging Research

Background:

Microplastic (MP) health impacts are increasingly studied, but long-term human risks remain unclear.
The influence of MPs on aging rate is a potential indicator of remote health effects.
Accelerated senescence OXYS rats, prone to geriatric diseases, were used to model aging processes.

Purpose of the Study:

To investigate the effects of chronic microplastic administration on aging indicators.
To assess MP influence on hematological, biochemical, cognitive, and ocular parameters in rats.
To evaluate MP-induced changes in age-related diseases like cataracts and AMD.

Main Methods:

Polyethylene terephthalate MPs (2-6 microns) were administered to OXYS and Wistar rats (10 or 100 mg/kg/day, 1.5-3.5 months).
Hematological and biochemical blood parameters were analyzed.
Spatial learning and memory were assessed.
Cataract and retinopathy development were evaluated in OXYS rats.

Main Results:

Chronic MP administration impaired cognitive functions in both Wistar and OXYS rats.
No significant changes were observed in standard clinical blood parameters.
A high MP dose (100 mg/kg) accelerated cataract and AMD progression in OXYS rats.

Conclusions:

Microplastics may accelerate the aging process.
Long-term exposure to microplastics could potentially impact lifespan.
Cognitive decline and exacerbation of age-related eye diseases are potential risks associated with microplastic exposure.