Combining Cold Atmospheric Plasma and Environmental Nanoparticle Removal Device Reduces Neurodegenerative Markers

Area of Science:

• Neuroscience
• Environmental Health
• Biotechnology

Background:

• Aging causes brain deterioration and neurodegeneration, marked by tau hyperphosphorylation and beta-amyloid deposition.
• Cellular changes like energy depletion and impaired protein synthesis precede these markers and can be exacerbated by environmental pollution.
• Cold Atmospheric Plasma (CAP) shows potential for cellular improvement, but its organ-level effects, especially in conjunction with pollution mitigation, are unclear.

Purpose of the Study:

• To investigate the impact of a device combining CAP treatment and environmental nanoparticle removal on aged mouse brains.
• To assess the effects on cellular energy, stress, and clearance mechanisms.
• To evaluate the reduction of key neurodegeneration markers.

Main Methods:

• Aged mice were treated with a device integrating Cold Atmospheric Plasma (CAP) and environmental nanoparticle removal.
• Brain activity, cellular stress markers, and protein aggregation were analyzed.
• Key indicators of neurodegeneration, including tau hyperphosphorylation and beta-amyloid deposition, were quantified.

Main Results:

• The treatment increased brain energy capacity and activated cellular autophagic clearance.
• It significantly reduced endoplasmic reticulum stress and minimized aggresome formation.
• Key markers of neurodegeneration, tau hyperphosphorylation and beta-amyloid deposition, were substantially reduced.

Conclusions:

• The combined CAP and nanoparticle removal device effectively improved aged mouse brain function at the organ level.
• This approach mitigates cellular stress and enhances waste clearance, thereby reducing neurodegenerative markers.
• The findings highlight a novel therapeutic strategy for age-related brain health and neurodegeneration.