Related Experiment Video
Updated: Jun 4, 2025
11:11
Isolation of Sertoli Cells and Peritubular Cells from Rat Testes
Published on: February 8, 2016
22.4K
Mast Cells as a Component of Spermatogonial Stem Cells' Microenvironment
Ali Sadek1,2, Yulia Khramtsova3, Boris Yushkov3
1Department of Biology and Fundamental Medicine, Ural Federal University Named After the First President of Russia B. N. Yeltsin, 620002 Ekaterinburg, Russia.
International Journal of Molecular Sciences
|December 17, 2024
Summary
Testicular mast cells (MCs) are crucial regulators of spermatogenesis. This review explores their impact on spermatogonial stem cells (SSCs) and male fertility in both healthy and diseased states.
Area of Science:
- Reproductive Biology
- Cell Biology
- Immunology
Background:
- Spermatogenesis, the production of mature spermatozoa, originates from spermatogonial stem cells (SSCs).
- The SSC niche, a microenvironment within the seminiferous tubules, is critical for maintaining SSCs and regulating spermatogenesis.
- Testicular mast cells (MCs) are immune cells within the testes that produce bioactive substances influencing physiological processes.
Purpose of the Study:
- To review the effects of testicular mast cells (MCs) on spermatogonial stem cells (SSCs).
- To explore the role of MCs in regulating spermatogenesis under normal and pathological conditions.
- To examine MC interactions within the testicular microenvironment and their impact on male fertility.
Main Methods:
- Literature review of studies on testicular mast cells and spermatogenesis.
- Analysis of the molecular and cellular interactions within the SSC niche.
- Examination of the role of MC-derived factors in regulating SSC behavior and sperm production.
Main Results:
- Testicular MCs significantly influence SSC maintenance, differentiation, and self-renewal.
- MCs modulate spermatogenesis through the release of various bioactive mediators.
- Dysregulation of MCs is associated with pathological conditions affecting male fertility.
Conclusions:
- Testicular mast cells play a critical role in regulating spermatogenesis and maintaining male fertility.
- Understanding MC-SSC interactions is essential for addressing infertility causes.
- Targeting testicular MCs may offer therapeutic strategies for fertility disorders.
More Related Videos
12:26Serial Enrichment of Spermatogonial Stem and Progenitor Cells SSCs in Culture for Derivation of Long-term Adult Mouse SSC Lines
Published on: February 25, 2013
13.8K
09:18Extra Cellular Matrix-Based and Extra Cellular Matrix-Free Generation of Murine Testicular Organoids
Published on: October 7, 2020
6.8K
Related Concept Videos
01:41Spermatogenesis
102.1K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.1K
01:19Mesenchymal Stem Cells
4.6K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.6K
01:26Stem Cell Niche
5.0K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
5.0K
01:01Regulation of Hematopoietic Stem Cells
3.1K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.1K
02:17The Tumor Microenvironment
6.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.5K
01:06Multipotency and Niche of Bulge Stem Cell
3.4K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
3.4K