Sex Differences in Clinical Features in Gout: A Nationwide Retrospective Cohort Study
Hyunsue Do1, Kwanyoung Choe2, Min Jung Kim3
1Division of Rheumatology, Department of Internal Medicine, Kangwon National University School of Medicine, 156 Baengnyeong-ro, Chuncheon-si 24289, Republic of Korea.
Journal of Clinical Medicine
|December 17, 2024
Summary
Gout patients
Area of Science:
- Rheumatology
- Epidemiology
- Gerontology
Background:
- Gout is associated with comorbidities impacting patient mortality.
- Understanding sex-specific differences in gout patients is crucial for effective management.
- Korean National Health Insurance Service data provides insights into gout patient populations.
Purpose of the Study:
- To analyze clinical manifestations in Korean gout patients.
- To compare causes of death between male and female gout patients.
- To identify sex-specific risk factors for all-cause mortality in gout.
Main Methods:
- Retrospective cohort study using Korean National Health Insurance Service-National Sample Cohort data (2002-2019).
- Inclusion of adult gout patients receiving urate-lowering therapy (ULT).
- Comparison of clinical features and causes of death by sex; multivariate Cox regression for risk factor analysis.
Main Results:
- Female gout patients were older at ULT initiation and had more comorbidities.
- Chronic kidney disease (CKD) was the leading cause of death overall; lung cancer in males, CKD in females.
- Significant mortality risk factors included age at ULT start, low BMI, smoking, diabetes, CKD, cerebrovascular disease, malignancy, and low hemoglobin, with variations between sexes.
Conclusions:
- Significant sex-based differences exist in clinical presentation and mortality causes among gout patients.
- Tailored treatment strategies for gout should consider sex-specific factors.
- Further research into sex-specific management of gout comorbidities is warranted.
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