Related Experiment Video
Updated: Jun 4, 2025
13:10
Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli
Published on: September 25, 2016
9.9K
Enhanced Hypercoagulability Using Clot Waveform Analysis in Patients with Acute Myocardial Infarction and Acute
Jun Masuda1, Hideo Wada2, Takashi Kato1
1Department of Cardiology, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan.
Journal of Clinical Medicine
|December 17, 2024
Summary
Routine clotting tests miss hypercoagulability in heart attack and stroke patients. Clot waveform analysis of activated partial thromboplastin time (APTT) and tissue factor assays show promise for detecting this dangerous hypercoagulable state.
Area of Science:
- Hematology
- Cardiovascular Medicine
- Neurology
- Diagnostic Medicine
Background:
- Standard activated partial thromboplastin time (APTT) and prothrombin time (PT) lack sensitivity for detecting hypercoagulability in acute myocardial infarction (AMI) and acute cerebral infarction (ACI).
- Hypercoagulability is a critical factor in the pathogenesis of thrombotic events like AMI and ACI.
Purpose of the Study:
- To evaluate the efficacy of clot waveform analysis (CWA) using APTT and a small amount of tissue factor activation assay (sTF/FIXa) in identifying hypercoagulable states in patients with AMI or ACI.
- To determine if specific CWA parameters can serve as reliable biomarkers for hypercoagulability in these patient populations.
Main Methods:
- Hypercoagulability assessment in patients with AMI or ACI using CWA of APTT and sTF/FIXa.
- Analysis of CWA parameters including derivative peak time (DPT), derivative peak height (DPH), derivative peak width (DPW), and area under the curve (AUC).
- Receiver operating characteristic (ROC) curve analysis to assess diagnostic performance against healthy volunteers (HVs) and non-thrombotic states.
Main Results:
- While standard APTT did not indicate hypercoagulability, CWA revealed significant differences.
- The second DPT of CWA-sTF/FIXa was significantly shorter in ACI patients compared to HVs.
- DPH values for both CWA-APTT and CWA-sTF/FIXa were significantly higher in AMI and ACI patients versus HVs. ROC analyses demonstrated AUC values >0.800 for DPH, AUC, and AUC/second DPT, indicating strong diagnostic potential.
Conclusions:
- Clot waveform analysis parameters, particularly the AUC/second DPT of CWA-APTT and CWA-sTF/FIXa, show significant potential for detecting hypercoagulable states in patients experiencing AMI and ACI.
- These advanced CWA metrics offer a more sensitive approach to identifying thrombotic risk compared to routine coagulation tests.
