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Updated: Jun 4, 2025

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PIK3CA Mutations and Co-Mutations in Operated Non-Small Cell Lung Carcinoma

Salih Cokpinar1, Ibrahim Halil Erdogdu2, Seda Orenay-Boyacioglu3

  • 1Department of Thoracic Surgery, School of Medicine, Aydin Adnan Menderes University, Aydin 09010, Türkiye.

Journal of Clinical Medicine
|December 17, 2024
PubMed

Insights

This study found PIK3CA mutations in all non-small cell lung carcinoma (NSCLC) patients, with common variants like E545K. These PIK3CA mutations, alongside others like KRAS and TP53, are crucial for personalized NSCLC treatment strategies.

Area of Science:

  • Oncology
  • Molecular Pathology
  • Genetics

Background:

  • Understanding PIK3CA mutations and co-mutations is vital for personalized non-small cell lung carcinoma (NSCLC) treatment.
  • This study investigates PIK3CA mutations and associated somatic variations in NSCLC patients.

Purpose of the Study:

  • To investigate PIK3CA mutations and accompanying somatic variations in non-small cell lung carcinoma (NSCLC).
  • To identify common PIK3CA variants and co-occurring mutations for potential targeted therapy development.

Main Methods:

  • Retrospective analysis of 98 NSCLC patients undergoing next-generation sequencing and ALK-ROS1 FISH analysis.
  • Data collected between January 2019 and June 2024 from patients aged over 18.

Main Results:

  • All 98 NSCLC patients analyzed harbored PIK3CA mutations.
  • The most frequent PIK3CA variants included c.1633G>A p.E545K (32.65%), c.1624G>A p.E542K (11.22%), and c.3140A>G p.H1047R (11.22%).
  • Commonly co-occurring mutations involved KRAS, NF1, TP53, and EGFR.

Conclusions:

  • PIK3CA variations, frequently observed in NSCLC, are critical in cancer progression.
  • The presence of PIK3CA and other gene variations significantly influences the determination of targeted treatment strategies for NSCLC.
Keywords:
NSCLCPIK3CA mutationco-mutationsmoking history

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