N6-methyladenosine (m6A) modification in inflammation: a bibliometric analysis and literature review

Area of Science:

• Molecular Biology
• Immunology
• Bioinformatics

Background:

• N6-methyladenosine (m6A) is the most prevalent internal mRNA modification in eukaryotes.
• m6A regulates RNA metabolism, influencing diverse physiological and pathological processes.
• Its role in inflammatory responses and diseases is a growing area of research.

Purpose of the Study:

• To systematically evaluate the research landscape on the association between m6A and inflammation.
• To identify key research trends, countries, institutions, and authors in this field.
• To summarize potential mechanisms by which m6A regulates inflammation.

Main Methods:

• Bibliometric analysis using VOSviewer and Citespace.
• Literature search conducted on the Web of Science Core Collection.
• Analysis of publication characteristics including year, country, institution, author, journal, citation, and keywords.

Main Results:

• The study identified key research trends and influential contributors in m6A and inflammation research.
• Bibliometric analysis of keywords highlighted significant research clusters.
• Potential regulatory mechanisms of m6A in inflammation were summarized based on keyword analysis.

Conclusions:

• m6A plays a significant role in modulating inflammatory responses.
• Key mechanisms include regulation of apoptosis, autophagy, oxidative stress, immune cell function, and signaling pathways.
• This bibliometric analysis provides a comprehensive overview of the current research status and future directions.