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Bioavailability Enhancement: Drug Solubility Enhancement01:16

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Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
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Optimization of Instant Beverage Powder Containing Propolis Extract Nanoliposomes.

Mehdi Mirzazadeh1, Hadiseh Bagheri2, Fatemeh Rasi3

  • 1Department of Food Science and Technology, Faculty of Agriculture, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran.

International Journal of Food Science
|December 17, 2024
PubMed
Summary
This summary is machine-generated.

Encapsulating propolis extract in nanoliposomes enhances its stability and bioavailability. This study optimized its use in an instant drink formulation, improving beverage quality and sensory attributes.

Keywords:
RSMdrinkencapsulationfortificationnanoliposomepropolis

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Area of Science:

  • Food Science and Technology
  • Biomaterials Engineering
  • Nutraceuticals

Background:

  • Propolis, a bee-derived resin, contains bioactive compounds with therapeutic potential.
  • Instability and poor bioavailability limit propolis's efficacy.
  • Encapsulation, particularly using nanoliposomes, offers a solution to enhance propolis delivery.

Purpose of the Study:

  • To encapsulate propolis extract using nanoliposomes.
  • To incorporate nanoliposome-encapsulated propolis into an instant drink formulation.
  • To optimize the formulation using Response Surface Methodology (RSM) and evaluate its characteristics.

Main Methods:

  • Nanoliposome encapsulation of propolis extract.
  • Characterization of nanoliposomes (particle size, zeta potential, encapsulation efficiency).
  • Formulation of instant drinks with varying nanoliposome concentrations (0-5%) and optimization using RSM.

Main Results:

  • Nanoliposomes exhibited optimal characteristics: 255 nm particle size, -37.6 mV zeta potential, and 73.71% encapsulation efficiency.
  • RSM predicted 3.19% nanoliposome concentration for the best beverage quality.
  • The optimized formulation maintained sensory attributes while improving overall quality.

Conclusions:

  • Nanoliposome encapsulation is effective for stabilizing and delivering propolis bioactive compounds.
  • Propolis-enriched instant drinks can be successfully developed using this technology.
  • This approach enhances nutraceutical delivery and beverage quality.