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Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
Published on: October 21, 2022
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Corneal stromal mapping characteristics in normal corneas using anterior segment SD-OCT.
Mohammad Abusamak1,2, Sara Mazen Issa1, Amal F Alomari1
1Department of Special Surgery, School of Medicine, Al-Balqa Applied University, Al-Salt, Jordan.
Frontiers in Medicine
|December 17, 2024
Summary
Corneal stromal thickness (CST) varies across the cornea, being thinnest centrally and thickest superiorly. Age influences CST, with a positive correlation noted in the 30-49 age group, impacting eye care strategies.
Area of Science:
- Ophthalmology
- Corneal Imaging
- Biometry
Background:
- Understanding normal corneal stromal thickness (CST) is crucial for ophthalmic diagnostics and surgical planning.
- Age, sex, and intraocular pressure (IOP) are potential factors influencing corneal biomechanics.
- Anterior segment spectral-domain optical coherence tomography (AS-OCT) is a key tool for corneal assessment.
Purpose of the Study:
- To investigate the influence of age, sex, and corrected intraocular pressure (IOP) on normal corneal stromal profiles.
- To characterize the distribution of corneal stromal thickness (CST) across the central 6-mm corneal diameter.
- To provide data relevant to refractive surgery planning and corneal disease diagnosis in the Jordanian population.
Main Methods:
- Retrospective observational analytical study involving 134 eyes from individuals aged 18-79.
- Utilized anterior segment spectral-domain optical coherence tomography (AS-OCT) to measure corneal stromal thickness (CST).
- Analyzed CST data in relation to age groups, sex, and corrected intraocular pressure (IOP), excluding specific ocular conditions.
Main Results:
- A centrifugal distribution of CST was observed, with the central stroma being thinnest (484.6 ±32.6 μm) and the superior peripheral zone being thickest (549.3 ±40.6 μm).
- A positive correlation was found between CST and the 30-49 age group.
- No significant correlation was found between CST and corrected IOP or sex.
Conclusions:
- Corneal stromal thickness exhibits a distinct centrifugal pattern, with implications for understanding corneal structure.
- AS-OCT is a valuable tool for detailed corneal stromal assessment, aiding in refractive surgery and disease diagnosis.
- The findings offer insights into the interplay of age and corneal stromal characteristics, informing clinical management in the Jordanian population.
