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Aerococcus urinae urinary tract infections: A case series
Sofia Maraki1, Viktoria Eirini Mavromanolaki2, Dimitra Stafylaki1
11Department of Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, 71500 Crete, Greece.
Acta Microbiologica Et Immunologica Hungarica
|December 17, 2024
Summary
Aerococcus urinae is an uncommon cause of urinary tract infections (UTIs), primarily affecting the elderly. This study found high susceptibility rates to common antibiotics, suggesting effective treatment options for A. urinae UTIs.
Area of Science:
- Microbiology
- Infectious Diseases
- Urology
Background:
- Aerococcus urinae is an infrequent cause of urinary tract infections (UTIs), predominantly seen in elderly individuals with comorbidities.
- Understanding the clinical profile and antimicrobial resistance patterns of A. urinae is crucial for effective patient management.
Purpose of the Study:
- To investigate the clinical and microbiological characteristics of patients with UTIs caused by A. urinae.
- To determine the antimicrobial susceptibility patterns of A. urinae isolates over a three-year period.
Main Methods:
- Retrospective analysis of medical and microbiological data from patients with A. urinae in urine cultures (2020-2022).
- Identification of isolates using matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS).
- Antimicrobial susceptibility testing via disk diffusion and MIC Test Strip for fosfomycin, interpreted using EUCAST 2024 breakpoints.
Main Results:
- A. urinae was identified in 24 patients, with a median age of 72 years; females were slightly more prevalent.
- Comorbidities including urologic disease, chronic lung/kidney disease, heart disease, diabetes, and dementia were present in 79.2% of patients.
- High susceptibility rates were observed for penicillin, amoxicillin, meropenem, and vancomycin (100%); notable susceptibility was also seen for nitrofurantoin (95.8%) and fosfomycin (91.7%).
Conclusions:
- Aerococcus urinae infections predominantly affect elderly individuals with significant underlying health conditions.
- The study demonstrates high in vitro susceptibility of A. urinae to several commonly used antibiotics, including penicillin, amoxicillin, meropenem, and vancomycin.
- Further research, including clinical trials, is warranted to confirm these findings and assess the in vivo efficacy of antimicrobial agents for treating A. urinae UTIs.
Keywords:
Aerococcus urinaeGreeceantimicrobial susceptibilityunderlying diseasesurinary tract infectionsMore Related Videos
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