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Association Between Chronotype and Chronic Neuropathic Pain Sensitivity: A Pilot Prospective, Observational,

Michael Kim1, Yuri C Martins2, Kishan Patel3

  • 1University of Arizona Medical School, Tucson, AZ.

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Morning chronotype individuals experience higher neuropathic pain intensity but less pain interference. This suggests morning chronotypes are more sensitive to pain but less functionally impaired by it.

Keywords:
circadian rhythmdepressioneveningnesslarkmorningnessnight owlsleepChronic pain

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Area of Science:

  • Neurology
  • Sleep Medicine
  • Pain Management

Background:

  • Chronotype, an individual's sleep-wake preference, is linked to pain sensitivity.
  • Morning chronotypes show protection against musculoskeletal pain and headaches.
  • The association between chronotype and neuropathic pain sensitivity is not well understood.

Purpose of the Study:

  • To investigate the relationship between chronotype, neuropathic pain sensitivity, and pain interference.
  • To explore predictors of pain intensity and interference in chronic neuropathic pain patients.

Main Methods:

  • Prospective, observational, cross-sectional pilot study.
  • Utilized the Morningness-Eveningness Questionnaire (MEQ) for chronotype assessment.
  • Employed linear mixed-effects models, PCA, and PCR for data analysis.

Main Results:

  • Morning chronotype patients reported higher pain intensity (NRS scores).
  • Morning chronotype patients reported lower pain interference (PROMIS-PI scores).
  • MEQ, depression, sleep apnea risk, sleep quality, and BMI predicted pain scores.

Conclusions:

  • Morning chronotypes exhibit increased sensitivity to neuropathic pain.
  • Despite higher sensitivity, morning chronotypes experience less interference from pain.
  • Larger studies are required to confirm these findings in diverse populations.