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3-Halo-3-nitro-aza/thioflavanones: DNMT inhibitors with a two-site binding mode in the hDNMT3A catalytic pocket

Alexandra Serhouni1, Francesco Calzaferri1, Yannick Bessina1

  • 1Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, CNRS-Université de Montpellier-ENSCM, 1919 route de Mende, 34296 Montpellier cedex 5, France.

Bioorganic & Medicinal Chemistry
|December 17, 2024
PubMed

Keywords:
Binding modesDNA methylationDNMT inhibitorsEpigenetics

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