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Updated: Jun 4, 2025
Scalable High Throughput Selection From Phage-displayed Synthetic Antibody Libraries
Published on: January 17, 2015
Expanding the landscape of antibody discovery
Shelbe Johnson1, Brandon J DeKosky2
1Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA; The Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA.
None:
Library:library screening technologies hold substantial promise for paired antibody:antigen discovery, but challenges have persisted. In this issue of Cell Reports Methods, Wagner et al. introduce a method that combines antibody-ribosome-mRNA complexes, antigen cell surface display, and single-cell RNA sequencing to successfully screen diverse antibody gene libraries against a library of viral receptor proteins.
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