[Experimental and clinical basis for the use of 111In-DTPA for radionuclide cisternography]

Modern radiopharmaceuticals are used to get information on the anatomy and function of the liquor system, i. e. they make it possible to monitor a radionuclide biological behavior in vivo by external detection. Complex compounds like diethylene triamine pentacetic acid (DTPA) labeled with 111In or 99mTc are the most common radionuclides used abroad to study the liquor system pathology. The clinicoexperimental studies on the use of the 111In-Ca-DTPA complex for radionuclide cisternography elaborated in this country, took 2 years. Experiments on animals showed that 70% of the administered amount of the radionuclide left the liquor pathways 4 h later. The administration of a clinical dose 5 times as high demonstrated the drug safety. The Soviet radiopharmaceutical was evaluated by comparing under clinical conditions 3 radionuclides: 111In-DTPA (France), 99mTc-DTPA (FRG) and 111In-Ca-DTPA (USSR). The radiological picture of radionuclide distribution by the liquor pathways did not depend on the drug. Radiological signs showed a direct correlation with a disease entity.