Related Experiment Video
Updated: Jun 4, 2025
09:45
On-Chip Octanol-Assisted Liposome Assembly for Bioengineering
Published on: March 17, 2023
2.5K
Development of ROS-triggered masked liposomes for activated cellular delivery using a charge balance strategy
Mayesha B Mustafa1, Jinchao Lou1, Miranda A Phillips1
1Department of Chemistry, 1420 Circle Drive, Knoxville, TN 37996-1600, USA. mdbest@utk.edu.
Chemical Communications (Cambridge, England)
|December 18, 2024
Abstract
None:
We report a charge balance strategy for reactive oxygen species (ROS)-triggered activation of liposome cell delivery by unmasking cationic membranes. Zeta potential experiments, microplate-based vesicle interaction assays, and cellular delivery studies confirmed that modification of anionic lipid 1 by ROS led to the uncaging of cationic liposomes, thereby driving cellular association.
