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Updated: Jun 4, 2025

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
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Therapeutic Persistence in the Management of Familial Hypercholesterolemia: A Case of Acquired PCSK9 Inhibitor

Kevin H Lin1, Neil J Stone1

  • 1Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.

JACC. Case Reports
|December 18, 2024
PubMed

Insights

Familial hypercholesterolemia (FH) management can be challenging, especially with statin intolerance. A novel approach using inclisiran successfully lowered low-density lipoprotein cholesterol in a patient with FH and cardiovascular disease.

Area of Science:

  • Cardiology
  • Genetics
  • Metabolic Disorders

Background:

  • Familial hypercholesterolemia (FH) is an inherited lipid metabolism disorder causing high LDL cholesterol and premature cardiovascular disease.
  • Managing FH is complex, often requiring persistent treatment adjustments to reach lipid targets, particularly in patients with existing atherosclerotic cardiovascular disease.

Keywords:
dyslipidemiashypercholesterolemialipid metabolism disordersprimary preventionsecondary prevention

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