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Comparing the Efficacy of Intralesional Injection versus Systemic Steroids in Treating Idiopathic Granulomatous
Buşra Burcu1, Işık Çetinoğlu1, Nadir Adnan Hacim2
1General Surgery Department, Şişli Etfal Training and Research Hospital, Istanbul, Turkey.
Objective:
Idiopathic granulomatous mastitis (IGM) is a benign inflammatory condition predominantly affecting women of reproductive age, particularly those with a history of breastfeeding. Although the precise etiology remains unknown, treatment strategies continue to be a subject of debate. This study aimed to compare the efficacy of intralesional steroid (ILS) injections with oral steroid (OS) therapy in managing IGM.
Materials And Methods:
A total of 72 patients, clinically and histopathologically diagnosed with IGM, were treated with either ILSs (group ILS, n = 47) or OSs (group OS, n = 25) at a tertiary referral hospital between January 2022 and January 2024. The data were retrospectively analyzed.
Results:
The mean age of the patients was 33.5 years (range: 22-56). No statistically significant differences were observed between the two groups in terms of demographic characteristics, presenting symptoms, clinical findings, or laboratory results. The mean treatment duration was 6 months. There were no significant differences in treatment response or recurrence rates between the two groups. However, there was a statistically significant difference in the incidence of side effects, with 6.3% in the ILS group compared to 36% in the OS group (p = 0.001).
Conclusion:
Given its ease of application, lower incidence of side effects, and comparable efficacy, ILS injections may be considered a first-line treatment option in the management of IGM.
