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Related Experiment Video

Updated: Jun 4, 2025

Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke

Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke

Published on: February 10, 2023

Macrowire for Intracranial Thrombectomy: A Video Description.

Arjun B Kumar¹, Usama Khan¹, Kaustubh Limaye²

¹Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.

Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences

|December 18, 2024

Summary

This study introduces a novel mechanical thrombectomy technique for acute ischemic stroke, utilizing a macrowire to guide large catheters directly to the clot. This approach avoids crossing the clot, potentially reducing fragmentation and distal embolization.

Keywords:

Stroke thrombectomy thrombectomy technique

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Last Updated: Jun 4, 2025

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A Procedure for Implanting Organized Arrays of Microwires for Single-unit Recordings in Awake, Behaving Animals

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Published on: February 14, 2014

Area of Science:

Neurology
Interventional Neuroradiology
Medical Devices

Background:

Mechanical thrombectomy is standard for acute ischemic stroke with large vessel occlusion.
Current techniques (ADAPT, SOLUMBRA) involve crossing the clot, risking fragmentation and embolization.

Purpose of the Study:

To present a novel mechanical thrombectomy technique using a macrowire without a microcatheter or microwire.
To evaluate the feasibility of delivering an ultra-large bore catheter directly to the occlusion.

Main Methods:

An ultra-large bore catheter (Sofia 0.088) was delivered over a macrowire (Aristotle Colossus) to the intracranial occlusion.
The technique bypasses the need to cross the clot with guidewires or microcatheters.

Main Results:

Successful delivery of the ultra-large bore catheter to the occlusion site was demonstrated.
The macrowire provided adequate support for catheter navigation.
The technique avoids crossing the clot, preventing potential clot disruption and distal embolization.

Conclusions:

This macrowire-guided thrombectomy technique offers a promising alternative for acute ischemic stroke.
Potential benefits include reduced clot fragmentation, distal embolization, and improved time/cost efficiency, currently under investigation in the MINT Registry.