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Profile of co-occurring or secondary infections among COVID-19 patients with HBOT: a single-center retrospective

Peixia Yu1, Hairu Wang1, Ziyang Li1

  • 1Department of Laboratory Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, China.

Journal of Infection in Developing Countries
|December 18, 2024
PubMed

Insights

This study analyzed co-occurring infections in hospitalized COVID-19 patients with and without hyperbaric oxygen therapy (HBOT). HBOT patients had fewer infections, but those with HBOT showed specific multidrug-resistant organisms (MDROs).

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Hyperbaric Medicine

Background:

  • Hospitalized coronavirus disease 2019 (COVID-19) patients may develop co-occurring or secondary infections.
  • Hyperbaric oxygen therapy (HBOT) is used in treating some COVID-19 patients.
  • Understanding infection profiles in these patients is crucial for effective management.

Purpose of the Study:

  • To describe the profile of co-occurring or secondary infections in hospitalized COVID-19 patients.
  • To compare infection characteristics between COVID-19 patients who received HBOT and those who did not.

Main Methods:

  • Retrospective analysis of 716 COVID-19 patients, focusing on 79 with co-occurring or secondary infections.
  • Categorization into HBOT and non-HBOT groups.
  • Collection and analysis of clinical data, laboratory results, pathogen distribution, and antimicrobial susceptibility.

Main Results:

  • 73 out of 79 patients had infections; 62 had co-occurring or secondary infections.
  • Influenza virus was common in non-HBOT patients but absent in HBOT patients.
  • HBOT patients showed prevalent infections with Klebsiella pneumoniae, Corynebacterium striatum, Acinetobacter baumannii, and multidrug-resistant organisms (MDROs).

Conclusions:

  • The study characterizes in-hospital co-occurring or secondary infections in North China COVID-19 patients.
  • Management of infections, particularly MDROs in HBOT-treated patients, requires strengthening.
  • Further research into infection control strategies for COVID-19 patients undergoing HBOT is warranted.
Abstract

Keywords:
COVID-19HBOTMDROsco-occurring infectionscoronavirus disease-19hyperbaric oxygen therapymultidrug-resistant organismssecondary infections

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