Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Gate-Tunable Thermal Persistent Photocurrent Device for In-Sensor Spiking Neural Networks.

ACS applied materials & interfaces·2026
Same author

Abnormal Chiral Coupling for Efficient and Stable Reduced-Dimensional Perovskite Emitters.

ACS nano·2026
Same author

Modulating Persistent Photoconductivity through Barrier Engineering for High-performance and Multifunctional Two-dimensional Optoelectronic Devices.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Quantitative determination of lateral spatial resolution in confocal Raman microscopy using graphene cross-edge scanning.

The Review of scientific instruments·2026
Same author

Plasmonic nanocavity-enabled universal detection of layer-breathing vibrations in two-dimensional materials.

Light, science & applications·2026
Same author

Wearable In Situ SERS Sensors Based on the Metal@MOF Particle-in-Cavity Model: Suitable for Detection of Multifarious Biomarkers in Different Biofluids of Humans.

ACS sensors·2026

Related Experiment Video

Updated: Jun 4, 2025

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092
08:53

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092

Published on: October 2, 2017

29.8K

Advanced SERS Platform for Uniform and Reliable Molecular Detection.

Tiying Zhu1,2, Zhiyang Pei2, Xiaofei Zhao2

  • 1School of Physics and Optoelectronic Engineering, Beijing University of Technology, Beijing 100124, China.

Analytical Chemistry
|December 18, 2024
PubMed
Summary

This study presents a novel hierarchical silver nanopore and microbowl platform with superhydrophobic/superhydrophilic treatments to improve surface-enhanced Raman scattering (SERS) uniformity for reliable molecular detection.

More Related Videos

The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform
10:01

The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform

Published on: September 27, 2016

7.6K
High-throughput Detection of Respiratory Pathogens in Animal Specimens by Nanoscale PCR
11:00

High-throughput Detection of Respiratory Pathogens in Animal Specimens by Nanoscale PCR

Published on: November 28, 2016

11.9K

Related Experiment Videos

Last Updated: Jun 4, 2025

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092
08:53

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092

Published on: October 2, 2017

29.8K
The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform
10:01

The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform

Published on: September 27, 2016

7.6K
High-throughput Detection of Respiratory Pathogens in Animal Specimens by Nanoscale PCR
11:00

High-throughput Detection of Respiratory Pathogens in Animal Specimens by Nanoscale PCR

Published on: November 28, 2016

11.9K

Area of Science:

  • Nanotechnology
  • Analytical Chemistry
  • Spectroscopy

Background:

  • Signal uniformity is critical for quantitative surface-enhanced Raman scattering (SERS) measurements.
  • Localized hot spots and the coffee ring effect hinder SERS signal consistency.

Purpose of the Study:

  • To develop a SERS platform that enhances signal uniformity and enables reliable molecular detection.
  • To mitigate the challenges posed by hot spots and the coffee ring effect in SERS.

Main Methods:

  • Fabrication of a hierarchical structure with Ag nanopores and microbowls (HANM).
  • Application of superhydrophobic/superhydrophilic (SHB/SHL) treatments to the HANM platform.
  • Analysis of rhodamine 6G (R6G) and bisphenol A (BPA) using the developed SERS platform.

Main Results:

  • The HANM-SHB/SHL platform demonstrated enhanced hot spot area and mitigated the coffee ring effect, leading to even analyte distribution.
  • Excellent SERS signal uniformity was achieved, with a relative standard deviation of 3.81% for R6G detection.
  • Consistent and uniform BPA detection was achieved across various environmental water samples.

Conclusions:

  • The developed dual-function SERS platform offers improved hot spot regions and effectively avoids the coffee ring effect.
  • This platform provides a foundation for precise and reliable quantitative molecular analysis.
  • The HANM-SHB/SHL structure shows significant potential for sensitive and uniform detection in complex samples.